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Mitochondrial function disturbance is a key event in numerous pathological conditions, such as hypoxic-ischemic injuries, stroke, and diabetes

In the propagation phase, a lipid radical reacts with oxygen, producing a lipid peroxyl radical (LOO) that may interact with another lipid (L), making a LOOH and another lipid radical (L) that can repeat the cycle [34]

Even illness, pregnancy, and certain medications can cause deficiencies

Gastrointestinal Issues As mentioned, the most common side effects are gut-related

This accumulation is accompanied by downregulation of glutathione peroxidase 4 (GPX4), upregulation of acyl-CoA synthetase long-chain family member 4 (ACSL4), and elevated lipid peroxidationhallmarks of ferroptotic cell death (Taylor et al., 2008)